Evaluación técnico-económica y diseño conceptual de un proceso de producción de 2,3-butanediol a partir de bagazo de caña de azúcar en Cuba

Autores/as

DOI:

https://doi.org/10.70881/mcj/v4/n1/116

Palabras clave:

2,3-butanediol, bagazo de caña de azúcar, evaluación técnico-económica, valor actual neto, análisis de sensibilidad

Resumen

El 2,3-butanediol (2,3-BDO) tiene un gran potencial para diversas industrias, incluyendo la química, cosmética, agrícola y farmacéutica. El presente trabajo tiene como objetivo realizar la evaluación técnico-económica preliminar y diseño conceptual de una planta de producción de 2,3-BDO a partir de bagazo de caña de azúcar por la ruta fermentativa mediante el empleo del simulador SuperPro DesignerÒ, con el fin de determinar los indicadores productivos y de rentabilidad más importantes bajo las condiciones económicas actuales de Cuba. La planta procesará 400 toneladas métricas (TM) de bagazo por año y producirá anualmente 40 TM de 2,3-BDO. Se necesitan USD $ 26,589 millones para erigir la planta de producción propuesta, con un costo de operación anual de USD $ 1,483 millones y unas ganancias netas anuales de USD $ 5,520 millones. Se obtendrá un valor actual neto, tasa interna de retorno y periodo de recuperación de la inversión de 14,067 millones, 18,56% y 4,82 años, siempre y cuando el precio de venta del 2,3-BDO sea de USD $ 220/kg. El estudio de sensibilidad realizado indica que, para un precio unitario de venta de 2,3-BDO menor de USD $ 150/kg, la propuesta tecnológica comienza a ser no rentable. El proyecto de planta simulado en este estudio se clasifica como no competitivo debido a que el precio de venta del 2,3-BDO fijado para obtener indicadores económicos rentables y factibles es muy superior al rango establecido internacionalmente y en otros estudios para este indicador

Descargas

Los datos de descarga aún no están disponibles.

Referencias

Afschar, A. S., Bellgardt, K. H., Rossell, C. E. V., Czok, A., & Schaller, K. (1991). The production of 2,3-butanediol by fermentation of high test molasses. Applied Microbiology and Biotechnology, 34, 582-585. https://doi.org/10.1007/BF00167903 DOI: https://doi.org/10.1007/BF00167903

Amraoui, Y., Narisetty, V., Coulon, F., Agrawal, D., Chandel, A. K., Maina, S., . . . Kumar, V. (2021). Integrated Fermentative Production and Downstream Processing of 2,3-Butanediol from Sugarcane Bagasse-Derived Xylose by Mutant Strain of Enterobacter ludwigii. ACS Sustainable Chemistry & Engineering, 9, 10381-10391. https://doi.org/10.1021/acssuschemeng.1c03951 DOI: https://doi.org/10.1021/acssuschemeng.1c03951

Brown, T. (2006). Engineering Economics and Economic Design for Process Engineers. CRC Press.

Cheali, P., Gernaey, K. V., & Sin, G. (2015). Uncertainties in early-stage capital cost estimation of process design – a case study on biorefinery design. Frontiers in Energy Research, 3(3), 1-13. https://doi.org/10.3389/fenrg.2015.00003 DOI: https://doi.org/10.3389/fenrg.2015.00003

Cho, S., Kim, T., Woo, H. M., Lee, J., Kim, Y., & Um, Y. (2015). Enhanced 2,3-Butanediol Production by Optimizing Fermentation Conditions and Engineering Klebsiella oxytoca M1 through Overexpression of Acetoin Reductase. PLoS ONE, 10(9), e0138109. https://doi.org/10.1371/journal.pone.0138109 DOI: https://doi.org/10.1371/journal.pone.0138109

Couper, J. R., Penney, W. R., Fair, J. R., & Walas, S. M. (2012). Chemical Process Equipment Selection and Design (3rd ed.). Butterworth-Heinemann. DOI: https://doi.org/10.1016/B978-0-12-396959-0.00017-3

Ebrahimian, F., & Mohammadi, A. (2024). Bioprocess Design and Technoeconomic Analysis of 2,3-Butanediol Production in Wood-Based Biorefineries. Waste and Biomass Valorization, 15, 6635–6648. https://doi.org/10.1007/s12649-024-02611-3 DOI: https://doi.org/10.1007/s12649-024-02611-3

Gadkari, S., Narisetty, V., Maity, S. K., Manyar, H., Mohanty, K., Jeyakumar, R. B., . . . Kumar, V. (2023). Techno-Economic Analysis of 2,3-Butanediol Production from Sugarcane Bagasse. ACS Sustainable Chemistry & Engineering, 11, 8337-8349. https://doi.org/10.1021/acssuschemeng.3c01221 DOI: https://doi.org/10.1021/acssuschemeng.3c01221

Garg, S. K., & Jain, A. (1995). Fermentative production of 2,3-butanediol: A review. Bioresource Technology, 51, 103-109. https://doi.org/10.1016/0960-8524(94)00136-O DOI: https://doi.org/10.1016/0960-8524(94)00136-O

Green, D. W., & Southard, M. Z. (2019). Perry's Chemical Engineers' Handbook (9th ed.). McGraw-Hill Education.

Harrison, R. G., Todd, P. W., Rudge, S. R., & Petrides, D. P. (2015). Bioseparations Science and Engineering (2nd ed.). Oxford University Press. DOI: https://doi.org/10.1093/oso/9780195391817.001.0001

Hazeena, S. H., Shurpali, N. J., Siljanen, H., Lappalainen, R., Anoop, P., Adarsh, V. P., . . . Binod, P. (2022). Bioprocess development of 2, 3butanediol production using agroindustrial residues. Bioprocess and Biosystems Engineering, 45, 1527–1537. https://doi.org/10.1007/s00449-022-02761-5 DOI: https://doi.org/10.1007/s00449-022-02761-5

Jenkins, S. (2025). Economic Indicators. Chemical Engineering, 132(6), 44.

Köpke, M., Mihalcea, C., Liew, F., Tizard, J. H., Ali, M. S., Conolly, J. J., . . . Simpson, S. D. (2011). 2,3-Butanediol Production by Acetogenic Bacteria, an Alternative Route to Chemical Synthesis, Using Industrial Waste Gas. Applied and Environmental Microbiology, 77(15), 5467–5475. https://doi.org/10.1128/AEM.00355-11 DOI: https://doi.org/10.1128/AEM.00355-11

Koutinas, A. A., Yepez, B., Kopsahelis, N., Freire, D. M. G., Castro, A. M. d., Papanikolaou, S., & Kookos, I. K. (2016). Techno-economic evaluation of a complete bioprocess for 2,3-butanediol production from renewable resources. Bioresource Technology, 204, 55-64. http://dx.doi.org/10.1016/j.biortech.2015.12.005 DOI: https://doi.org/10.1016/j.biortech.2015.12.005

Lahiri, S. K. (2020). Profit Maximization Techniques for Operating Chemical Plants. John Wiley & Sons Ltd. DOI: https://doi.org/10.1002/9781119532231

Lam, K. F., Leung, C. C. J., Lei, H. M., & Lin, C. S. K. (2014). Economic feasibility of a pilot-scale fermentative succinic acid production from bakery wastes. Food and Bioproducts Processing, 92, 282-290. http://dx.doi.org/10.1016/j.fbp.2013.09.001 DOI: https://doi.org/10.1016/j.fbp.2013.09.001

Lee, C. S., Chong, M. F., Binner, E., Gomes, R., & Robinson, J. (2018). Techno-economic assessment of scale-up ofbio-flocculant extraction and production by usingokra as biomass feedstock. Chemical Engineering Research and Design, 132, 358-369. https://doi.org/10.1016/j.cherd.2018.01.050 DOI: https://doi.org/10.1016/j.cherd.2018.01.050

Lee, Y., & Seo, J. (2019). Production of 2,3butanediol from glucose and cassava hydrolysates by metabolically engineered industrial polyploid Saccharomyces cerevisiae. Biotechnology for Biofuels, 12, 204. https://doi.org/10.1186/s13068-019-1545-1 DOI: https://doi.org/10.1186/s13068-019-1545-1

Mailaram, S., Narisetty, V., Ranade, V. V., Kumar, V., & Maity, S. K. (2022). Techno-Economic Analysis for the Production of 2,3-Butanediol from Brewers’ Spent Grain Using Pinch Technology. Industrial and Engineering Chemistry Research, 61, 2195−2205. https://doi.org/10.1021/acs.iecr.1c04410 DOI: https://doi.org/10.1021/acs.iecr.1c04410

Narisetty, V., Amraoui, Y., Abdullah, A., Ahmad, E., Agrawal, D., Parameswaran, B., . . . Kumar, V. (2021). High yield recovery of 2,3-butanediol from fermented broth accumulated on xylose rich sugarcane bagasse hydrolysate using aqueous two-phase extraction system. Bioresource Technology, 337, 125463. https://doi.org/10.1016/j.biortech.2021.125463 DOI: https://doi.org/10.1016/j.biortech.2021.125463

Narisetty, V., Narisetty, S., Jacob, S., Kumar, D., Leeke, G. A., Chandel, A. K., . . . a, V. K. (2022). Biological production and recovery of 2,3-butanediol using arabinose from sugar beet pulp by Enterobacter ludwigii. Renewable Energy, 191, 394-404. https://doi.org/10.1016/j.renene.2022.04.024 DOI: https://doi.org/10.1016/j.renene.2022.04.024

Nugroho, D. S., Yu-Shen, C., Chou, T.-H., Hartini, N., & Chiu, H.-Y. (2019). Antifungal Lotion as Value-Added Product for Harvested BSFL Processing: Simple Process Design and Economic Evaluation. Jurnal Bahan Alam Terbarukan, 8(2), 124-132. https://doi.org/10.15294/jbat.v8i2.22794 DOI: https://doi.org/10.15294/jbat.v8i2.22794

Okonkwo, C. C., Duduyemi, A., Ujor, V. C., Atiyeh, H. K., Iloba, I., Qureshi, N., & Ezeji, T. C. (2023). From AgriculturalWastes to Fermentation Nutrients: A Case Study of 2,3-Butanediol Production. Fermentation, 9, 36. https://doi.org/10.3390/fermentation9010036 DOI: https://doi.org/10.3390/fermentation9010036

ONEI. (2025). Industria Manufacturera. https://www.onei.gob.cu/industria-manufacturera

Pahlavanzadeh, H., Khayati, G., & Vasheghani-Farahani, E. (2009). Extractive Capacity of Oleyl Alcohol on 2, 3-Butanediol Production in Fermentation Process with Use of Klebsiella pneumoniae PTCC 1290. Iran. J. Chem. Chem. Eng., 28(3), 103-109. https://doi.org/10.30492/ijcce.2009.6853

Peters, M. S., Timmerhaus, K. D., & West, R. E. (2003). Plant Design and Economics for Chemical Engineers (5th ed.). McGraw-Hill.

Radoš, D., Carvalho, A. L., Wieschalka, S., Neves, A. R., Blombach, B., Eikmanns, B. J., & Santos, H. (2015). Engineering Corynebacterium glutamicum for the production of 2,3-butanediol. Microbial Cell Factories, 14, 171. https://doi.org/10.1186/s12934-015-0362-x DOI: https://doi.org/10.1186/s12934-015-0362-x

Rehman, S., Islam, M. K., Khanzada, N. K., Zhuang, H., Wang, H., Chaiprapat, S., & Leu, S.-Y. (2021). Sustainability index accounting food and carbon benefits on circular 2,3-butanediol biorefinery with oil palm empty fruit bunches. Applied Energy, 303, 117667. https://doi.org/10.1016/j.apenergy.2021.117667 DOI: https://doi.org/10.1016/j.apenergy.2021.117667

Roncal, T., Maestro, B., & Prieto-Fernandez, S. (2023). Fermentative production of 2,3-butanediol from cheese whey by a non-engineered mutant strain of Lactococcus lactis. Bioresource Technology Reports, 24, 101637. https://doi.org/10.1016/j.biteb.2023.101637 DOI: https://doi.org/10.1016/j.biteb.2023.101637

Rosales-Calderon, O., & Arantes, V. (2019). A review on commercialscale highvalue products that can be produced alongside cellulosic ethanol. Biotechnology for Biofuels, 12, 240. https://doi.org/10.1186/s13068-019-1529-1 DOI: https://doi.org/10.1186/s13068-019-1529-1

Sánchez, A. P., Misailidis, N., Ferreira, R. G., & Petrides, D. (2024). 2,3-Butanediol (BDO) Production from Sugarcane Bagasse via Fermentation - Process Modeling and Evaluation using SuperPro Designer®. ReadMe File, 1-20. https://doi.org/10.13140/RG.2.2.11927.38564

Sikazwe, M. K., Louw, J., & Görgens, J. F. (2024). Microbe and bioprocess performances for sustainable production of biobased 2,3-butanediol in a sugarcane biorefinery; a technoeconomic and environmental analysis. Clean Technologies and Environmental Policy, 26, 4505-4519. https://doi.org/10.1007/s10098-024-02843-w DOI: https://doi.org/10.1007/s10098-024-02843-w

Sinnott, R., & Towler, G. (2020). Chemical Engineering Design (6th ed.). Oxford, UK: Butterworth-Heinemann.

Stoklosa, R. J., Latona, R. J., & Johnston, D. B. (2022). Assessing oxygen limiting fermentation conditions for 2,3-butanediol production from Paenibacillus polymyxa. Frontiers in Chemical Engineering, 4, 1038311. https://doi.org/10.3389/fceng.2022.1038311 DOI: https://doi.org/10.3389/fceng.2022.1038311

Suttikul, S., Charalampopoulos, D., & Chatzifragkou, A. (2023). Biotechnological Production of Optically Pure 2,3-Butanediol by Bacillus subtilis Based on Dissolved Oxygen Control Strategy. Fermentation, 9, 15. https://doi.org/10.3390/fermentation9010015 DOI: https://doi.org/10.3390/fermentation9010015

Tinôco, D., Borschiver, S., Coutinho, P. L., & Freire, D. M. G. (2020). Technological development of the bio-based 2,3-butanediol process. Biofuels, Bioproducts and Biorefining. https://doi.org/10.1002/bbb.2173 DOI: https://doi.org/10.1002/bbb.2173

Tiwari, B. R., Bhar, R., Dubey, B. K., Maity, S. K., Brar, S. K., Kumar, G., & Kumar, V. (2023). Life Cycle Assessment of Microbial 2,3-Butanediol Production from Brewer’s Spent Grain Modeled on Pinch Technology. ACS Sustainable Chemistry & Engineering, 11, 8271-8280. https://doi.org/10.1021/acssuschemeng.3c00616 DOI: https://doi.org/10.1021/acssuschemeng.3c00616

Wang, D., Oh, B., Lee, S., Kim, D., & Joe, M. (2021). Process optimization for mass production of 2,3butanediol by Bacillus subtilis CS13. Biotechnology for Biofuels, 15, 15. https://doi.org/10.1186/s13068-020-01859-w DOI: https://doi.org/10.1186/s13068-020-01859-w

Zang, G., Shah, A., & Wan, C. (2020). Techno-economic analysis of co-production of 2,3-butanediol, furfural, and technical lignin via biomass processing based on deep eutectic solvent pretreatment. Biofuels, Bioproducts and Biorefining. https://doi.org/10.1002/bbb.2081 DOI: https://doi.org/10.1002/bbb.2081

Descargas

Publicado

2026-01-22

Cómo citar

Jiménez-Guerra, L., Pérez-Sánchez, A., & Alcalá-Galiano-Morell, D. D. (2026). Evaluación técnico-económica y diseño conceptual de un proceso de producción de 2,3-butanediol a partir de bagazo de caña de azúcar en Cuba. Multidisciplinary Collaborative Journal, 4(1), 144-165. https://doi.org/10.70881/mcj/v4/n1/116

Artículos similares

91-100 de 128

También puede Iniciar una búsqueda de similitud avanzada para este artículo.

Artículos más leídos del mismo autor/a

1 2 3 4 5 6 7 8 9 10 > >>